Book

Publications of Kőhidai, L.

KPA (HAS) document

(IF, citation, statistics)

Books:

Kőhidai, L.: A kemotaxis biológiai és klinikai jelentősége /1996, Budapest/

Kőhidai, L., Szabó, L., Láng, O. A kemotaxis mérése prokaryota és eukaryota sejtekben. Biomedica Hungaria; ISBN-13: 978-963-06-1603-4; /Budapest, 2007/

Fókuszban a kemotaxis. (szerk. Kőhidai, L., Dul, Cs.) Biomedica Hungaria; /Budapest, 2007/

Chapters:

1. Kőhidai, L., Kovács, P., Nozawa, Y. and Csaba, G. Drug induced membrane perturbation in Tetrahymena pyriformis, studies on lectin binding.

In: Proc. Symp. Biol. Hung. 33, pp. 179-184 /1986/

2. Barsony, J., McKoy, W., Smith, C., De Marco, L., Kőhidai, L., Libermann, U.A. and Marx, S.J. Heterogeneous functions of normal or mutant receptors for vitamin D.

In: Proc. 10th Int. Congr. Calcium on Regulating Hormones. Elsevier Sci Publ., Amsterdam, pp. 77-82 /1991/

3. Illyés, E., Kőhidai, L., Bősze, Sz., Láng, O., Vékey, K., Medzihradszky-Schweiger, H., Sebestyén, F. and Hudecz, F. New chemotactic peptides.

In: Peptides 2000, Proc. 26th Eur. Peptide Symp., Montpellier, France (Martinez, J., Fehrentz, J.-A., Eds.), Éditions EDK, Paris, pp. 227-228., /2000/

4. Mező, G., Kalászi, A., Mihala, N., Reményi, J., Majer, Zs., Láng, O., Kőhidai, L., Barna, K., Gaál, D. Synthesis of new carrier molecules based on repeated tuftsin sequences.

In: Peptides 2000, Proc. 26th Eur. Peptide Symp., Montpellier, France (Martinez, J., Fehrentz, J.-A., Eds.), Éditions EDK, Paris, pp. 253-254., /2001/

5. Illyés, E., Láng, O., Kőhidai, L., Bősze, Sz., Sebestyén, F., Hudecz, F. Synthesis of SXWS peptides and their chemotactic activity on a ciliated protozoan Tetrahymena pyriformis.

In: Peptides 2002, Proc. 27th Eur. Peptide Symp., Sorrento, Italy (Benedetti, E., Pedone, C. Eds.), Edizioni Ziino, Napoli, pp. 514-515, /2002/

6. Szabó, R., Illyés, E., Mező, G., Schiess, N., Kőhidai, L., Hudecz, F. Influence of polymer peptides and IL-6R peptides on chemotaxis of the macrophage-like cell line J774.

In: Peptides 2002, Proc. 27th Eur. Peptide Symp., Sorrento, Italy (Benedetti, E., Pedone, C. Eds.), Edizioni Ziino, Napoli, pp. 514-515, /2002/

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7. Jakab, A., Mező, G., Láng, O., Török, K., Kőhidai, L., Hudecz, F. Synthesis and chemotactic activity of conjugates containing For-Met-Leu-Phe chemotactic peptide.

In: Peptides 2004 (Eds.M. Flegel, M. Fridkin, Ch. Gilon, J. Slaninova) Kenes International, Israel, pp. 429-430, /2005/

8. Kőhidai, L. A vezikuláris transzport folyamatának genetikai és proteomikai háttere.

In: Fejezetek a genomléptékű biológiából és orvostudományból. Semmelweis Kiadó, Budapest (Szerk. Falus A.) pp.117-142, /2006/

9. Bai, K.B., Láng, O., Szabó, I., Kőhidai, L., Hudecz, F., Mező, G. Chemotactic drug targeting (CDT) Synthesis and in vitro application of chemotactic drug delivery systems.
In: Peptides 2008, Proceedings of the 30th Eur. Peptide Symp., (Ed.: Lankinen, H.) Helsinki, Finland, pp.196-197 (2008)

Papers in English:

1. Kovács, P., Kőhidai, L., Csaba, G. Cyclic changes in lectin binding to the membrane of Tetrahymena. Acta Biol. Hung. 34, 117-120 /1983/

2. Kőhidai, L., Kovács, P. and Csaba G. Cyclic changes of concanavalin-A binding sites in Tetrahymena cell membrane. Acta Morphol. Hung. 33, 117-121 /1985/

3. Kőhidai, L. and Csaba, G. Effects of insulin and histamine in themselves and in combination on the glucose metabolism of Tetrahymena. Acta Biol. Hung. 36, 281-285 /1985/

4. Kőhidai, L., Kovács, P. and Csaba, G. Effect of inhibitors of protein synthesis and endocytosis on hormonal imprinting in the Tetrahymena. Acta Protozool. 24, 259-264 /1985/

5. Kovács, P., Kőhidai, L., Nozawa, Y. and Csaba, G.: Universality of hormonal imprinting in different taxa of Tetrahymena and inter-strain variations in its intensity. Acta Protozool. 24, 251-257 /1985/

6. Kőhidai, L., Muto, Y., Nozawa, Y. and Csaba, G. Studies on the interrelationship between hormonal imprinting and membrane potential in modell experiments on Tetrahymena. Cell. Mol. Biol. 32, 641-645 /1986/

7. Csaba, G. and Kőhidai, L. Modeling the insulin receptor in the Tetrahymena. Time-dependence of receptor formation, down-regulation and imprinting. Acta Protozool. 25, 331-338 /1986/

8. Kőhidai, L., Kovács, P., Nozawa, Y. and Csaba, G. Drug induced membrane perturbation in Tetrahymena pyriformis, studies on lectin binding. Symposia Biologica Hungarica 33, /1986/

9. Kőhidai. L., Kovács, P., Nozawa, Y. and Csaba, G. Effects of membrane fluidity changes on lectin binding of Tetrahymena pyriformis. Cell. Mol. Biol. 32, 303-308 /1986/

10. Kőhidai, L., Kovács, P., Nozawa, Y. and Csaba, G. Influence of phenothiazines and local anesthetics on lectin binding to Tetrahymena surface membrane. Cell. Mol. Biol. 32, 73-77 /1986/

11. Kőhidai, L., Thomka, M. and Csaba, G. Age of culture: a factor influencing hormonal imprinting of Tetrahymena. Acta Microbiol. Hung. 33, 295-300 /1987/

12. Kőhidai, L., Muto, Y. Nozawa, Y. and Csaba, G. Impact of changes in intracellular Ca2+ and K+ concentration on the development of hormonal imprinting in a Tetrahymena modell system. Cell Mol. Biol. 33, 265-274 /1987/

13. Kőhidai, L., Darvas, Zs. and Csaba, G. The effect of varying illumination on imprinting of Tetrahymena by insulin. Acta Microbiol. Hung. 34, 179-185 /1987/

14. Bohdaneczky, E., Csaba, G., Csiky J. and Kőhidai, L. Imprinting with oxytocin and vasopressin in chang liver cultures hormonal overlap, binding and influence on cell division. Acta Physiol. Hung. 71, 35-40 /1988/

15. Csaba, G. and Kőhidai, L. Interrelationship of hormone concentration, hormonal imprinting and receptor down-regulation in Tetrahymena. Acta Protozool. 28, 183-186 /1989/

16. Csaba, G. and Kőhidai, L. Overlap of concanavalin-A and insulin imprinting in rat thymocytes. Acta Physiol. Hung. 75, 107-110 /1990/

17. Kőhidai, L., Csaba, G. Impact of length of exposure to peptides of different molecular mass on the establishment of imprinting in Tetrahymena. Acta Protozool. 29, 315-319 /1990/

18. Kőhidai, L., Csaba, G. and László, V. Persistence of receptor "memory" induced in Tetrahymena by insulin imprinting. Acta Morphol. Hung. 37, 269-275 /1990/

19. Kőhidai, L. and Csaba, G. A functional study of the Dexamethasone-induced steroid receptor in Tetrahymena. Acta Protozool. 29, 73-79 /1990/ IF: 0.238

20. Kőhidai, L. and Csaba, G. Influence of encephalins on the ACTH-induced hormonal imprinting in Tetrahymena. Acta Physiol. Hung. 76, 21-26 /1990/

21. Kőhidai, L., Kihara, A. and Csaba, G. Correlation of insulin pretreatment and insulin binding of Amoeba proteus - A new technique for evaluation. Comp. Biochem. Physiol. 103A, 535-539 /1992/

22. Kőhidai, L., Barsony, J., Roth, J., Marx, S.J. Rapid effects of insulin on cyclic GMP location in an intact protozoan. Experientia 48, 476-481 /1992/

23. Kőhidai, L., Karsa, J. and Csaba, G. Effects of hormones on the chemotaxis in Tetrahymena - Investigations on receptor memory. Microbios 77, 75-85 /1994/

24. Csaba, G., Kovács, P. and Kőhidai, L. Tetrahymena cells distinguish insulins according to their amorphous and crystalline condition or their bovine and porcine origin. Study of imprinting in aspects of hormone binding and chemotaxis. Microbios 80, 215-221 /1994/

25. Kőhidai, L., Csaba, G. and Karsa, J. Effect of atrial natriuretic peptide /ANP/ on the unicellular model Tetrahymena pyriformis. Microbios 82, 27-40 /1995/

26. Kőhidai, L. Method for determination of chemoattraction in Tetrahymena pyriformis. Curr. Microbiol. 30, 251-253 /1995/

27. Kőhidai, L., Kovács, P. and Csaba, G. Chemotactic response of unicellular Tetrahymena to leukocyte attractant peptide and its repellent derivate. Evolutionary conclusions. Cell Biol. Internat. 18, 119-121 /1994/

28. Kőhidai, L., Lovas, B. and Csaba, G. Effect of adrenocorticotropic hormone (ACTH) and insulin on the phagocytic capacity of Tetrahymena. Zool. Sci. 12, 277-281 /1995/

29. Kőhidai, L., Lemberkovits, É. and Csaba, G. Molecule dependent chemotactic responses of Tetrahymena pyriformis elicited by volatile oils. Acta Protozool. 34, 181-185 /1995/

30. Kőhidai, L. and Csaba, G. Effects of the mammalian vasoconstrictor peptide, endothelin-1, on Tetrahymena pyriformis GL, and the immunocytological detection of endogenous endothelin -like activity. Comp. Biochem. Physiol. 111C, 311-316 /1995/

31. Csaba, G. and Kőhidai, L. Effects of L-alanine and L-alanine peptides on the chemotaxis of Tetrahymena: Evolutionary conclusions. Biosci. Rep. 15, 185-190 /1995/

32. Kőhidai, L. and Csaba, G. Different and selective chemotactic responses of Tetrahymena pyriformis to two families of signal molecules: lectins and peptide hormones. Acta Microbiol. Immunol. Hung. 43, 83-91 /1996/

33. Kőhidai, L., Kovács, P. and Csaba, G. Chemotaxis of the unicellular green alga Dunaliella salina and the ciliated Tetrahymena pyriformis - Effects of glycine, Lysine, and Alanine, and their oligopeptides. Biosci. Rep. 16, 467-476 /1996/

34. Kőhidai, L. and Csaba, G. Mitochondrial dehydrogenases in different taxa of Tetrahymena: effect of insulin . Biosci. Rep. 17, 529-535 /1997/

35. Kovács, P., Kőhidai, L. and Csaba, G. Effect of 3-amino-1-propanol on the phosphatidylinositol (PI) glycosyl phosphatidylinositol (GPI) systems of Tetrahymena. Comp. Biochem. Physiol. 118C, 83-87 /1997/

36. Kőhidai, L., Soós, P. and Csaba G. Effects of dipeptides containing the amino acid, proline on the chemotaxis of Tetrahymena pyriformis. Evolutionary conclusions on the formation of hormone receptors and hormones. Cell Biol. Internat. 21,341-5 /1997/

37. Kovács, P., Kőhidai, L. and Csaba, G. Effects of tumor nerosis factor a (TNF) on the phospholipid metabolism of Tetrahymena pyriformis. Cell Biochem. Function 16, 87-97 /1998/

38. Kőhidai, L. and Csaba, G. Chemotaxis and chemotactic selection induced with cytokines (IL-8, RANTES and TNF?) in the unicellular Tetrahymena pyriformis. Cytokine 10, 481-486 /1998/

39. Csaba, G., Gaál, Annamária, Kovács, P., Simon, G. and Kőhidai, L. Prolonged elevation of insulin content in the unicellular Tetrahymena after insulin treatment: induction of insulin production or storage ? Cell Biochem. Function 17, 165-173 /1999/

40. Kovács, P., Hegyesi, H., Kőhidai, L., Nemes, P. and Csaba, G. Effect of C ceramide on the inositol phospholipid metabolism /uptake of 32Pm 3H-serine and 3H-palmitic acid/ And apoptosis-related morphological changes in Tetrahymena. Comp. Biochem. Physiol. 122C, 215-224 /1999/

41. Kőhidai, L. Chemotaxis: The proper physiological response to evaluate phylogeny of signal molecules. Acta Biol. Hung. 50, 375-394 /1999/

42. Muto, Y., Kőhidai, L. Image analysis for recording cell locomotin. Bull. Coll. Gifu Univ 5, 87-93. /1999/

43. Kőhidai, L., Schiess, N. and Csaba, G. Chemotactic selection of Tetrahymena pyriformis GL induced with histamine, di-iodotyrosine or insulin. Comp. Biochem. Physiol. 126C, 1-9 /2000/

44. Kőhidai, L. Kovács, P., Lázár-Molnár, E., Csaba, G. Presence, uptake and localization of the cytokine, interleukine 6 /IL-6/ in the unicellular Tetrahymena pyriformis. Cell Biol. Internat. 24, 749-755 /2000/

45. Csaba, G., Kovács, Krisztina, Kőhidai, L. Effect of oxytocin and its analogues on the chemotaxis of Tetrahymena: evolutionary conclusions. Acta Protozool. 39, 345-347 /2000/

46. Bozóky, Z., Fülöp, L., Kőhidai, L. A short-run new analytical ultracentrifugal micromethod for determining low-density lipoprotein sub-fractions using Schlieren refractometry. Eur. Biophys. J. Biophys. Lett. 29, 621-627 /2001/

47. Schiess, N., Csaba, G., Kőhidai, L. Effect of selection with hormones (insulin, di-iodotyrosine and histamine) on the phagocytic responsiveness of Tetrahymena. Comp. Biochem. Physiol. 128C, 521-530 /2001/

48. Kőhidai, L., Tóth, K., Ruskoaho, H., Csaba, G. Effect of vasoactive peptides in Terahymena – Chemotactic properties of endothelins (ET-1, ET-2, ET-3, fragment 11-21 of ET-1 and big endothelin) – a short-term inducible signaling mechanism of chemotaxis. Cell. Biol. Internat. 25, 1173-1177 /2001/

49. Kőhidai, L., Keresztesi, M., Csaba, G. Effect of epidermal growth factor (EGF) to Tetrahymena pyriformis. Acta Protozool. 40, 221-224 /2001/

50. Kőhidai, L., Kovács, K. and Csaba, G. Direct chemotactic effect of bradykinin and related peptides – Significance of amino- and carboxyterminal character of oligopeptides in chemotaxis. Cell Biol. Internat. 26, 55-62 /2002/

51. Illyés, E., Hudecz, F., Kőhidai, L. Láng, O., Szabó, P., Sebestyén, F. Synthesis of Oligopeptides with SXWS Sequence and Their Chemotactic Effect on a Ciliated Protozoon Tetrahymena pyriformis. J. Peptide Sci. 8, 13-22 /2002/

52. Kőhidai, L., Vakkuri, O., Keresztesi, M., Pállinger, É., Leppäluoto, J., Csaba, G. Impact of melatonin on the cell division, phagocytosis and chemotaxis of Tetrahymena pyriformis. Acta Protozool. 41, 85-89 /2002/

53. Kovács, K., Kőhidai, L., Pállinger, É., Csaba, G. Effect of oxytocin and its analogues on the phagocytosis of Tetrahymena: outstanding impact of isotocin. Acta Protozool. 41, 191-197 /2002/

54. Illyés, E., Bősze, Sz., Láng, O., Kőhidai, L., Sebestyén, F., Hudecz, F. A new class of chemotactic peptides containing EWS motif: a minireview. Chim. Oggi 20, 55-61 /2002/

55. Kőhidai, L., Vakkuri, O., Keresztesi, M., Pállinger, É., Leppaluoto, J., Csaba, G. Melatonin in the unicellular Tetrahymena: effects of different lighting conditions regarding possible functions of melatonin at this low level of evolution. Cell Biochem Funct. 20, 269-272 /2002/

56. Kőhidai, L., Katona, J., Csaba, G. Effects of steroid hormones on five functional parameters of Tetrahymena: evolutionary conclusions. Cell Biochem. Funct. 21, 19-26 /2003/

57. Kőhidai, L., Bősze, Sz., Soós, P., Illyés, E., Láng, O., Mák, M., Sebestyén, F., Hudecz, F. Chemotactic activity of oligopeptides containing EWS motif on Tetrahymena pyriformis. The effect of amidation of the C-terminal residue. Cell Biochem. Funct. 21, 113-120 /2003/

58. Kőhidai, L., Bánky, Cs. Csaba, G. Comparison of lectin induced chemotactic selection and chemical imprinting in Tetrahymena pyriformis. Acta Protozool. 42, 91-97 /2003/

59. Szabó, R., Mező, G., Hudecz, F., Kőhidai, L. Effect of the polylysine based polymeric on the growth and chemotaxis of Tetrahymena pyriformis. J. Bioact. Compat. Polymers 17, 399-415 /2003/

60. Kőhidai, L., Vakkuri, O., Keresztesi, M., Leppäluoto, J. Csaba, G. Induction of melatonin synthesis in Tetrahymena pyriformis by hormonal imprinting - a unicellular „factory” of the indoleamine. Cell Mol. Biol. 49, 521-524 /2003/

61. Kőhidai, L., Török, K., Illyés, E., Tamási, J., Sebestyén, F., Láng, O., Csaba, Gy., Hudecz, F. Characterization of chemotactic ability to peptides containing N-formyl-methionyl residue in Tetrahymena model – for-Met-Leu-Phe (f-MLP) as a targeting ligand. Cell. Biol. Int. 27, 695-700 /2003/

62. Kőhidai, L., Láng, O., Csaba, G. Chemotactic-range-fitting of amino acids and its correlations to physicochemical parameters in Tetrahymena pyriformis – Phylogenetical consequences. Cell Mol. Biol. 49: OL487-495 /2003/

63. Kőhidai, L., Kun, L., Mihala, N., Csaba, G., Süli-Vargha, H. Cell-physiological effects of (VGVAPG)n elastin oligomers in a unicellular model system. J. Peptide Sci. 10, 427-438 /2004/

64. Mező, G., Kalászi, A., Reményi, J., Mihala, N., Majer, Zs., Hilbert, Á., Láng, O., Kőhidai, L., Barna, K., Gaál, D., Hudecz, F. Synthesis and biological studies of new carrier molecules based on repeated tuftsin sequences. Biopolymers 73, 645-656 /2004/

65. Mező G, Láng O, Jakab A, Bai KB, Szabó I, Schlosser G, Láng J, Kőhidai L, Hudecz F. Synthesis of oligotuftsin-based branched oligopeptide conjugates for chemotactic drug targeting. J Pept Sci. 12, 328-336 /2006/

66. Láng, O, Mező, G., Hudecz, F., Kőhidai, L. Effect of tuftsin and oligotuftsins on the chemotaxis and chemotactic selection of Tetrahymena pyriformis. Cell Biol. Int. 30, 603-609 /2006/

67. Szalai, C., Buzás, E.I., Fülöp, A.K., Kőhidai, L., Falus, A. Genomic strategies in pharmacology of asthma and autoimmunity. Anti-Inflamm. & Anti-Allergy Agents in Med. Chem. 5, 383-399 /2006/

68. Kőhidai, L., Gál, G., Banchetti, R. Interspecific effect of Er-1 and Er-2 Euplotes pheromones in Tetrahymena. Acta Zool. Sin. 52, 1125-1132 /2007/

69. Szabó, R.,Mező, G., Pállinger, É., Kovács, P., Kőhidai, L., Bősze, Sz., Hudecz, F. In vitro cytotoxicity, chemotactic effect and cellular uptake of branched polypeptides with poly[L-Lys] backbone by J774 murine macrophage cell line. Bioconjugate Chem. 19, 1078-1086 /2008/

70. Bai, B.K., Láng, O., Orbán, E., Szabó, R., Kőhidai, L., Hudecz, F., Mező, G. Design, synthesis and in vitro activity of recent drug delivery systems, containing tuftsin derivatives and methotrexate. Bioconjugate Chem. 19, 2260-2269 /2008/

71. Kim, D.H., Casale, D., Kőhidai, L., Kim, M.J. Galvanotactic and phototactic control of Tetrahymena pyriformis as a microfluidic workhorse. Appl. Phys. Lett. 94, 163901-163903 /2009/

72. Szabó R., Bánóczi Z., Mező G., Láng O., Kőhidai L., Hudecz F. Daunomycin-polypeptide conjugates with antitumor activity. Biochim Biophys Acta. 1798, 2209-2216 /2010/

73. Kim, D.H., Cheang, U.K., Kőhidai, L., Byun, D., Kim, M.J. Artificial magnetotactic motion control of Tetrahymena pyriformis using ferromagnetic nanoparticles A tool for fabrication of microbiorobots Applied Physics Lett. 97, 173702 /2010/

74. Sáfár, O., Kőhidai, L., Hegedűs, A. Time-delayed model of unibased movement of Tetrahymena pyriformis. Period. Math. Hung. 63, 215-225 /2011/

75. Láng, J., Rákász, V., Magyar, A., Pállinger, É., Kőhidai, L. Chemotactic effect of odorants and tastants on the ciliate Tetrahymena pyriformis. J. Rec. Sign. Transd. 31, 423-433 /2011/

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76. Lajkó, E. Polgár, L., Lengyel, J., Láng, O., Kőhidai, L., Magyar, K. Basic cell physiological activities (cell adhesion, chemotaxis, proliferation) induced by selegiline and its derivatives in Mono Mac 6 human monocytes. J. Neural Transm Online-First

77. Láng, O., Illyés, E., Menyhárd D.K., Láng, J., Sebestyén, F., Hudecz, F., Kőhidai, L. Chemotaxis induced by SXWS tetrapeptides in Tetrahymena—overlapping chemotactic effects of SXWS sequences and their identical amino acids. J. Mol. Recogn. (in press)

Short publications in international journals in English:

Kőhidai, L., Csaba, G. Chemosensory responses of Tetrahymena pyriformis GL to signal molecules. J. of Protozool. 43, 17A /1996/

Kőhidai, L., Csaba, G. Selective chemotactic response of Tetrahymena pyriformis to two families of signal molecules: lectins and peptide hormones. Cell Biol. Int. 20, 242 /1996/

Horkay, F., Bozóky, Z., Kőhidai, L., Fülöp, L. Investigation of low density lipoprotein subclass patterns with coronary heart disease. J. Mol. Cell. Cardiology 28A,102 /1996/

Mező, G., Kalászi, A., Reményi, J., Mihala, N., Majer, Zs., Láng, O., Kőhidai, L., Barna, K., Gaál, D. Synthesis of new carrier molecules based on repeated tuftsin sequences. J. Peptide Science 6(S), 99 /2000/

Szabó, R., Illyés, E., Mező, G., Schiess, N., Kőhidai, L., Hudecz, F. Influence of polymer polypeptides and IL-6R peptides on chemotaxis of the macrophage-like cell line J774. J. Pept. Sci . 8(S), 210 /2002/

Jakab, A., Mező, G., Láng, O., Török, K., Kőhidai, L., Hudecz, F. Synthesis and chemotactic activity of conjugates containing For-Met-Leu-Phe chemotactic peptide. J. Pept. Sci . 10(S), 163 /2004/

Láng, O., Birinyi, J., Bai, K., Mező, G., Hudecz, F., Kőhidai, L. Suitability of peptide conjugates containing formyl-peptide residue for chemotactic drug-targeting (CDT). FEBS Journal 272(S1), 527 /2005/

Kun, L., Süli-Vargha, H., Mihala, N., Tóth, M., Kőhidai, L. Effect of vasoactive peptides on adhesion and chemotaxis elicited by extracellular matrix protein sequences.(FEBS Journal 272(S1), 272 /2005/

Papers in Hungarian:

1. Kőhidai, L., Hámori, J.: Külföldi modellek – hazai tudománytámogatás. Magyar Tudomány 12, 1491-1498 /1997/

2. Kőhidai, L., Dérfalvy, B. Egy újonnan felfedezett molekulacsalád – A kemokinek. Lege Artis Medicinae 10, 666-678 /2000/.

3. Kőhidai, L. Az egysejtûek kemotaxisa. Élet és tudomány; 49, 55-58, /2000/